Prophylactic Theophyline reduces birth asphyxia related renal injury in term neonates

BACKGROUND INTRODUCTION: Birth Asphyxia (Perinatal Asphyxia) in newborn is a condition caused by the inadequate supply of oxygen before, during, or just after birth. Kidney most damaged organ asphyxiated full-term infants. Theophylline considered to be effective as adenosine antagonist reducing renal injury related birth asphyxia OBJECTIVE: To determine mean serum creatinine and glomerular filtration rate term neonates with perinatal prophylactic dose theophylline compared that control. MATERIALS AND METHODS: In this randomized controlled trial, total 60 fulfilling inclusion criteria were included study,--removed for blind review--. After taking written informed consent, all into either A (Theophylline group) B (Placebo group). group received single intravenous aminophylline (5 mg/kg, 0.25 ml/kg) while ml/kg normal saline was administered placebo over five-minute period within first hour presentation. Each patient evaluated using predesigned proforma. The 24-hour fluid intake urine output recorded during 5 days life. assess infant’s function, their creatinine, clearance (GFR) determined on one, three five between both groups. RESULTS: age cases 10.73 ± 8.11 hours control 14.33 7.52 hours. there 17(56.67%) male 13(43.33%) female cases. level 0.78 0.29 1.15 0.51 statistically lower group, p-value < 0.05. Glomerular 31.59 6.35 21.17 7.38 3with CONCLUSION: Through findings study, therapeutic efficacy confirmed terms maintaining rate. So, future function can protected introducing we reduce risk mortality. KEY WORDS: asphyxia, Sarnat grading system, theophylline,